Some common heterocyclic compound, 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine, molecular formula is C8H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-(3-Chlorophenyl)ethanamine
General procedure: 4.2.1. General procedure for the preparation of final target compounds The intermediate free acid (1 equiv) was dissolved in CH2Cl2(7 mL) followed by the addition of triethylamine (2.2 equiv). Thereaction was cooled to 0 C and stirred for 30 min. Then phenethy-lamine (1.1 equiv) and 4-dimethylaminopyridine (DMAP) (cat.,0.1 equiv) were added to the solution followed by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC-HCl)(1.1 equiv) in ve portions over 20 min. The solution stirred at0 C for 1 h then overnight at rt. The resulting solution was dis-solved in an additional CH2Cl2 (25 mL), and washed with sat. NH4-Cl (10 mL). The aqueous layer was extracted with CH2Cl2(3 10 mL), organic layers combined, and sequentially washedwith 20 mL of each of the following: sat. NaHCO3,H2O, brine. Theorganic layer was dried over Na2SO4 and concentrated to give aresidue which was further puried with Celite (100% ethyl acet-ate). Then, the sample was dissolved in EtOAc, solution was heated,and cooled to 0 C. The solution was ltered to yield desiredproduct.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 13078-79-0, its application will become more common.
Reference:
Article; Gromek, Samantha M.; deMayo, James A.; Maxwell, Andrew T.; West, Ashley M.; Pavlik, Christopher M.; Zhao, Ziyan; Li, Jin; Wiemer, Andrew J.; Zweifach, Adam; Balunas, Marcy J.; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5183 – 5196;,
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