Adding a certain compound to certain chemical reactions, such as: 6940-78-9, name is 1-Bromo-4-chlorobutane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6940-78-9, Computed Properties of C4H8BrCl
General procedure: To a solution of 4-nitrophenol (10 mmol, 1.0 eq) in 25 mL acetonitrile was added K2CO3 (10 mmol, 1 eq) at room temperature and stirred for 30 min, afterwards, different haloalkanes (15 mmol, 1.5 eq) were added dropwise. 1-Bromo-2-chloroethane (for 24a, n = 2); 1-bromo-3-chloropropane (for 24b, n = 3); 1-bromo-4-chlorobutane (for 24c, n = 4). The mixtures were stirred at 80 C for 12-24 h. The reactions were monitoring with TLC (petroleum ether: EtOAc = 4:1). Upon completion, water was added, the aqueous layer was extracted with EtOAc (25 mL × 3) and the combined organic layers were washed with brine. Evaporated the solvent to give the crude products 24a-c.
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Reference:
Article; Zhai, Zheng; Li, Ridong; Bai, Xinyu; Ning, Xianling; Lin, Zhiqiang; Zhao, Xuyang; Jin, Yan; Yin, Yuxin; Bioorganic and Medicinal Chemistry; vol. 27; 18; (2019); p. 4124 – 4142;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics