Synthetic Route of 622-24-2,Some common heterocyclic compound, 622-24-2, name is (2-Chloroethyl)benzene, molecular formula is C8H9Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamide (A) (35 g, 2.1 mol) and (2-chloroethyl)benzene (B) (32.8 g, Mix 2.52 mol) and add 50% sodium hydroxide solution (55ml),In a flask of a mixture of petroleum ether (72 ml) and copper iodide (5.07 g, 0.78 mol), the reaction was carried out at 85C for 9 hours. After the reaction was completed, the temperature was lowered to 6C to obtain of 3-ethyl-4-methyl-2-oxo-N-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide (C) (53.8 g) in a yield of 85.24%.Purity is 99.78%.
The synthetic route of 622-24-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dong Dandan; (7 pag.)CN107963988; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics