Electric Literature of 2106-02-7, These common heterocyclic compound, 2106-02-7, name is 2-Chloro-4-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 8; Synthesis of N-(2-chloro-4-fluoropheny?-N-(2-cvano-4-fluorophenv?-2-(5- isoquinolinyloxy)acetamide; 1 ) 2-[Y2-chloro-4-f*luorophenyl)amino1-5-fluorobenzonitrile; To a solution of 2-chloro-4-fluoroaniline (3.07 g) in N-methyl-2-pyrrolidone (40ml) was added potassium t-butoxide (4.97 g), the solution was stirred for 10 minutes, added 2,5-difluorobenzonitrile (3.26 g) in N-methyl-2-pyrrolidone (4ml), and then the solution was stirred for 4 hours at room temperature. While cooling on ice, water was added and then extraction was conducted with ethyl acetate. The organic phase was washed with water and a saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant residue was purified by a silica gel chromatography (hexane:chloroform=6: l to 1 : 1) to obtain an orange solid, which was washed with hexane (40 ml) to obtain the title compound (2.62 g) as a pale orange solid.
The synthetic route of 2106-02-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BANYU PHARMACEUTICAL CO.,LTD.; SUGIMOTO, Yuichi; SATOH, Atsushi; NISHIMURA, Teruyuki; WO2010/117084; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics