In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 870-24-6 as follows. Quality Control of 2-Chloroethanamine hydrochloride
beta- chloroethylamine hydrochloride 30g (0.26mol), phosphorusoxychloride 40g (0.26mol) were added in 200mL of dichloromethane and cooled to-20 deg.C. Under stirring, add dropwise triethylamine 26g (0.26mol) the methylenechloride solution 100mL. After the addition is complete, the reaction wasgradually raised to room temperature and reacted overnight. the solvent wasdistilled off under reduced pressure to reduced pressure distillation beta-chloroethylaminophosporylchloride 33.6 g, 53.6% yield.
According to the analysis of related databases, 870-24-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Beijing Institute of Technology; Wen, Hongliang; Shen, Xiurui; Huang, Cipan; Wang, Xiaodi; (47 pag.)CN105294756; (2016); A;,
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