Reference of 623-12-1,Some common heterocyclic compound, 623-12-1, name is 1-Chloro-4-methoxybenzene, molecular formula is C7H7ClO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 4-chioroanisole (62 iL, 0.50 mmol, I equiv), 1-napthylboronic acid (94 mg, 0.55 mmol, 1.1 equiv), and K3P04H20 (0.35 g, 1.5 mmol, 3 equiv) was added toluene (800a THF stock solution of 3 and PAd3 (100 pL, 0.25 .tmol Pd/PAd3) and the mixture was stirred at room temperature for 5 h. The reaction mixture was diluted with ethyl acetate then extracted with water. The combined organic layers were evaporated and the crude product waspurified by flash chromatography. After drying, 104 mg of 6 (89 %) was obtained as a white solid. NMR spectroscopic data agreed with literature values.
The synthetic route of 623-12-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE TRUSTEES OF PRINCETON UNIVERSITY; CARROW, Brad P.; CHEN, Liye; (51 pag.)WO2017/75581; (2017); A1;,
Chloride – Wikipedia,
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