Related Products of 95-81-8, These common heterocyclic compound, 95-81-8, name is 2-Chloro-5-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step C.; A solution of sodium nitrite (0.67 g, 9.94 mmol) and H2O (2.06 mL) was added dropwise at 0 C. to a solution of 2-chloro-5-methylbenzenamine (1.2 g, 8.29 mmol) in 12N HCl (12.8 mL) and TFA (2.5 mL). The reaction mixture was stirred at 0 C. for 1 h followed by the dropwise addition of a solution of tin(II)chloride (3.5 g, 18.2 mmol) in 12N HCl (4.9 mL) and H2O (0.7 ml) at 0 C. The reaction mixture stirred for 15 h at 20 C. and was filtered to give 1-(2-chloro-5-methylphenyl)hydrazine hydrochloride as a white solid (0.84 g, 4.3 mmol).
Statistics shows that 2-Chloro-5-methylaniline is playing an increasingly important role. we look forward to future research findings about 95-81-8.
Reference:
Patent; Bristol-Myers Squibb Company; US2007/27178; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics