Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104-52-9, name is 3-Phenylpropyl Chloride, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks
General procedure: Compounds A1-A20 were prepared following the previously reported method as described for A1 [1]. To a solution of 3-amino-5-mercapto-1,2,4-triazole (1.0 g, 8.61 mmol) in acetone was added sodium carbonate (1.37 g, 12.92 mmol) and alkyl halide (9.47 mmol). The mixture was then stirred at 60 oC for 3-6 h before cooling to room temperature. Upon completion of the reaction monitored by TLC, Na2CO3 were removed via filtration and the filtrate was evaporated under vacuum. The residue was purified by column chromatography, generating A1. 5-(((5-chlorobenzo[b]thiophen-3-yl)methyl)thio)-4H-1,2,4-triazol-3-amine, white solid, yield: 64 %.
The synthetic route of 104-52-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Shuai; Shen, Dandan; Zhao, Lijie; Yuan, Xiaohan; Cheng, Jialing; Yu, Bin; Zheng, Yichao; Liu, Hongmin; Chinese Chemical Letters; vol. 31; 2; (2020); p. 418 – 422;,
Chloride – Wikipedia,
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