These common heterocyclic compound, 622-86-6, name is (2-Chloroethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H9ClO
2-(4-Fluorophenyl)butanoic acid (250.3 mg, 1.4mmol) was suspended with stirring in trifluoroacetic anhydride (194.2 uL, 2.0mmol). Then (2-chloroethoxy)benzene (173 uL, 1.3 mmol) was added the resultingmixture was stirred at room temperature overnight. The reaction was quenchedwith saturated sodium bicarbonate solution (5 mL) and extracted with ethylacetate (2 x 15 mL). The combinedorganic layers were dried over anhydrous magnesium sulfate and concentrated ona rotary evaporator. The resultingresidue was purified by reverse-phased chromatography (C-10 column, gradient ofacetonitrile in water with 0.1% trifluoroacetic acid) to afford 105.2 mg (26%)of the desired product as a yellow solid.1H NMR (400 MHz, CDCl3) delta 7.90 (d, J=8.8 Hz, 2H), 7.50 (d,J=8.7 Hz, 2H), 7.23 (m, 2H), 6.95 (d, J=8.7 Hz, 2H), 4.25 (m, 3H), 3.86 (t,J=7.2 Hz, 2H), 2.18 (m, 1H), 1.60 (m, 1H), 0.90 (t, J=7.3 Hz, 3H); MS (ESI)(m/z) 321.1/323.1 (M+H)+.
The synthetic route of (2-Chloroethoxy)benzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
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