Related Products of 2106-04-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2106-04-9, name is 3-Chloro-2-fluoroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(2S, 4S)-4- (4-CHLORO-QUINAZOLIN-7-YLOXY)-PYRROLIDINE-1, 2-DICARBOXYLIC acid 1-tert-butyl ester 2-methyl ester (L. OG, 2.45mmol) and 3-CHLORO-2-FLUOROANILINE (323F1, 2. 94mmol) were stirred in acetonitrile (25ml) and hydrogen chloride (736JELL of a 4M solution in dioxane, 2. 94mmol) was added. The mixture was heated at reflux for 2h, cooled and concentrated under reduced pressure. The residue was dissolved in methanol, absorbed onto and ISOLUTEE SCX column, washed with methanol and eluted with 7N ammonia in methanol. Appropriate fractions were combined and evaporated and the crudes purified by column chromatography on silica eluting with 7N ammonia in METHANOL/DICBLOROMETHANE (2/98) to give methyl (4S)-4- ( {4- [ (3-CHLORO-2-FLUOROPHENYL) AMINO] QUINAZOLIN-7-YL} OXY)-L-PROLINATE (811MG, 79%) as a white SOLID. 1H NMR spectrum : (DMSO d6) 2.09 (M, 1H) ; 2.54 (M, 1H) ; 2.80 (brs, 1H); 3.15 (M, 2H) ; 3.64 (s, 3H); 3.81 (dd, 1H) ; 5.11 (M, 1H); 7.16 (M, 2H); 7.28 (t, 1H) ; 7.51 (M, 2H); 8.35 (d, 1H) ; 8.44 (s, 1H); 7.80 (s, 1H); Mass Spectrum: (MH)+ 417.
The synthetic route of 3-Chloro-2-fluoroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/30757; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics