Related Products of 20850-43-5, These common heterocyclic compound, 20850-43-5, name is 5-(Chloromethyl)benzo[d][1,3]dioxole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of the required pyrrole-2-carboxylic acid ethylester 9-12 (3 mmol), sodium hydride (4.5 mmol) and theappropriate arylmethylchloride (4.5 mmol) in dry dimethylformamide(5 mL) was stirred at room temperature for 48hours; after this time water was added and the resultingcrude material was extracted with diethyl ether (3 50 mL).The combined organic layers were dried over anhydroussodium sulphate, filtered, and concentrated under reducedpressure; the obtained residue was purified by means of flashchromatography using a mixture of ethyl acetate/cyclohexane (2:8, v:v) as eluent. Oil compounds 19 and 20 (yield: 55 and 53%, respectively) were immediately usedwithout further purification for the next step. Using this procedure,the following compounds were obtained:
Statistics shows that 5-(Chloromethyl)benzo[d][1,3]dioxole is playing an increasingly important role. we look forward to future research findings about 20850-43-5.
Reference:
Article; Salerno, Loredana; Modica, Maria N.; Romeo, Giuseppe; Pittala, Valeria; Cagnotto, Alfredo; Siracusa, Maria A.; Medicinal Chemistry; vol. 11; 2; (2015); p. 109 – 117;,
Chloride – Wikipedia,
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