Related Products of 104-11-0, A common heterocyclic compound, 104-11-0, name is 1-(4-Chlorophenyl)-N-methylmethanamine, molecular formula is C8H10ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 3-Hydroxybenzaldehyde (20 mmol) and the corresponding N-methylbenzylamine (8 mmol) were dissolved in methanol (5 mL). Acetic acid (0.4 mL) and sodium cyanoborohydride (16 mmol) were added and the mixture was stirred for 18 h at room temperature. The solvent was evaporated, the residue was suspended in satd. Na2CO3 solution(100 mL), and extracted with dichloromethane (3 x 50 mL). The combined organic layers were dried over sodium sulfate and evaporated. The residue was purified by flash column chromatography (1:1 hexane/ethyl acetate with 2 % N-ethyl-N,N-dimethylamine).
The synthetic route of 104-11-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wolfgardt, Annette; Bracher, Franz; Letters in Organic Chemistry; vol. 10; 1; (2013); p. 2 – 7;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics