Application of 7149-75-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7149-75-9 as follows.
In a 150 mL Schlenk tube equipped with a stirring bar, 5.79 g (22.0 mmol) of 4-bromodibenzothiophene represented by the above chemical formula (99), 4-chloro-3- 3.74 g (26.4 mmol) of methylaniline, 3.70 g (33.0 mmol) of potassium-tert-butoxide, 99 mg (0.44 mmol) of palladium (II) acetate and 60 mL of dehydrated toluene were placed and degassed and then tri- Butyl phosphine (267 mg, 1.32 mmol), and the mixture was sealed and stirred at 100 ° C. for 10 hours.After cooling to room temperature, the reaction mixture was poured into water, extracted with methylene chloride, and washed with water. After drying the organic layer with anhydrous sodium sulfate, the solvent was distilled off. The obtained crude product was purified by silica gel column chromatography using hexane: methylene chloride (4: 1) as an eluent.By carrying out the above steps, a compound represented by the above chemical formula (109) was obtained in a yield of 3.75 g in a yield of 53percent. Identification of the compound was carried out by mass spectrometry where the molecular ion peak matched with the object.
According to the analysis of related databases, 7149-75-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NIPPON HOSO KYOKAI <NHK>; KANTO CHEM CO INC; FUKAGAWA HIROHIKO; SHIMIZU TAKAHISA; TAKAHASHI JUNPEI; SHINNAI SATONOBU; TSUCHIYA KAZUHIKO; (53 pag.)JP2015/160849; (2015); A;,
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