Adding a certain compound to certain chemical reactions, such as: 622-86-6, name is (2-Chloroethoxy)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 622-86-6, Formula: C8H9ClO
2-(3-bromophenyl)aceticacid (4.0 g, 18.6mmol) was dissolved in trifluoroacetic anhydride (3.6 mL), then (2-chloroethoxy)benzene(2.56 mL, 19.5 mmol) was added dropwise. The resulting mixture was allowed tostir at room temperature for overnight. The reaction mixture was quenched with saturatedaqueous sodium bicarbonate and then extracted twice with ethyl acetate. Theorganic phases were combined and dried over anhydrous magnesium sulfate andconcentrated on a rotary evaporator. Purification with normal phasechromatography (ethyl acetate/hexane) afforded 5.46 g (83%) of the desiredproduct as a yellow solid (83%). 1H NMR (400MHz, CDCl3) delta 8.07 (d, J =8.9 Hz, 2H), 7.47-7.40(m, 2H), 7.25-7.24 (m, 2H), 7.07(d, J = 8.9 Hz, 2H), 4.35 (m, 4H), 3.92-3.89(m, 2H); MS (ESI) (m/z) 353.0/355.0 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Chloroethoxy)benzene, and friends who are interested can also refer to it.
Reference:
Article; Childers, Wayne; Fan, Rong; Martinez, Rogelio; Colussi, Dennis J.; Melenski, Edward; Liu, Yuxiao; Gordon, John; Abou-Gharbia, Magid; Jacobson, Marlene A.; Bioorganic and Medicinal Chemistry Letters; vol. 30; 2; (2020);,
Chloride – Wikipedia,
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