Adding a certain compound to certain chemical reactions, such as: 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1871-57-4, COA of Formula: C4H6Cl2
To a 500 mL two-necked flask equipped with a magnetic stirrer and a reflux device was added NaH (19.2 g, 0.8 mol, 7.4 eq.), Ar gas protection, Pumping gas three times, Anhydrous THF (250 mL) was added, 3-chloro-2-chloromethylpropylene (13.5 g, 0.11 mol, 1 eq.), 1-dodecanol (42.3 g, 0.227 mol, 2.1 eq.) Was added dropwise. The reaction was refluxed overnight at 65 deg C, Cooled to room temperature, Add water quenching reaction, Spin to spin to THF, Extracted with CH2Cl2 (50 mL x 3) Combine organic phase, Distilled water (50 mL x 3), The organic phase was dried over anhydrous magnesium sulfate, The magnesium sulfate was removed by filtration, Steaming the solvent, The residue was purified by silica gel column chromatography (eluent: PE / CH2Cl2 = 5/1) To give 32.4 g of a colorless liquid, Yield 75%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-2-chloromethyl-1-propene, and friends who are interested can also refer to it.
Reference:
Patent; Donghua University; Jin, Wusong; Zhang, Dengqing; Xiao, Duoduo; Li, Xianying; Chen, Beihua; Ning, Ruguang; Zhang, Zhen; (13 pag.)CN103819479; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics