Month: September 2021

HPLC of Formula: C7H4Cl2O2. Xi, Y; Yang, XH; Zhang, HY; Liu, HH; Watson, P; Yang, FF in [Xi, Yue; Yang, Xianhai; Zhang, Hongyu; Liu, Huihui] Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, Jiangsu Key Lab Chem Pollut Control & Resources R, Nanjing 210094, Peoples R China; [Watson, Peter; Yang, Feifei] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06268 USA published Binding interactions of halo-benzoic acids, halo-benzenesulfonic acids and halo-phenylboronic acids with human transthyretin in 2020, Cited 75. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

The anionic form-dependent binding interaction of halo-phenolic substances with human transthyretin (hTTR) has been observed previously. This indicates that ionizable compounds should be the primary focus in screening potential hTTR disruptors. Here, the potential binding potency of halo-benzoic acids, halo-benzenesulfonic acids/sulfates and halo-phenylboronic acids with hTTR was determined and analyzed by competitive fluorescence displacement assay integrated with computational methods. The laboratorial results indicated that the three test groups of model compounds exhibited a distinct binding affinity to hTTR. All the tested halo-phenylboronic acids, some of the tested halo-benzoic acids and halo-benzenesulfonic acids/sulfates were shown to be inactive with hTTR Other halo-benzoic acids and halo-benzenesulfonic acids/sulfates were moderate and/or weak hTTR binders. The binding affinity of halo-benzoic acids and halo-benzenesulfonic acids/sulfates with hTTR was similar. The low distribution ability of the model compounds from water to hTTR may be the reason why they exhibited the binding potency observed with hTTR. By introducing other highly hydrophobic compounds, we observed that the binding affinity between compounds and hTTR increased with increasing molecular hydrophobicity. Those results indicated that the highly hydrophobic halo-benzoic acids and halo-benzenesulfonic acids/sulfates may be high-priority hTTR disruptors. Finally, a binary classification model was constructed employing three predictive variables. The sensitivity (S-n), specificity (S-p), predictive accuracy (Q) values of the training set and validation set were >0.83, indicating that the model had good classification performance. Thus, the binary classification model developed here could be used to distinguish whether a given ionizable compound is a potential hTTR binder or not. (C) 2019 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H4Cl2O2. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Xi, Y; Yang, XH; Zhang, HY; Liu, HH; Watson, P; Yang, FF or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

An article Intermolecular interactions of substituted benzenes on multi-walled carbon nanotubes grafted on HPLC silica microspheres and interaction study through artificial neural networks WOS:000466872200010 published article about PERFORMANCE LIQUID-CHROMATOGRAPHY; STATIONARY-PHASE; QSAR; FUNCTIONALIZATION; MECHANISM; COLUMNS; ACIDS in [Merli, Daniele; Speltini, Andrea; Dondi, Daniele; Longhi, Diego; Milanese, Chiara; Profumo, Antonella] Univ Pavia, Dept Chem, Via Taramelli 12, I-27100 Pavia, Italy in 2019.0, Cited 48.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8. Safety of 1-Chloro-2-methylbenzene

Purified multi-walled carbon nanotubes (MWCNTs) grafted onto silica microspheres by gamma-radiation were applied as a HPLC stationary phase for investigating the intermolecular interactions between MWCNTs and substituted benzenes. The synthetic route, simple and not requiring CNTs derivatization, involved no alteration of the nanotube original morphology and physical-chemical properties. The affinity of a set of substituted benzenes for the MWCNTs was studied by correlating the capacity factor (k’) of each probe to its physico-chemical characteristics (calculated by Density Functional Theory). The correlation was found through a theoretical approach based on feedforward neural networks. This strategy was adopted because today these calculations are easily affordable for small molecules (like the analytes), and many critical parameters needed are not known. This might increase the applicability of the proposed method to other cases of study. Moreover, it was seen that the normal linear fit does not provide a good model. The interaction on the MWCNT phase was compared to that of an octadecyl (C18) reversed phase, under the same elution conditions. Results from trained neural networks indicated that the main role in the interactions between the analytes and the stationary phases is due to dipole moment, polarizability and LUMO energy. As expected for the C18 stationary phase correlation, is due to dipole moment and polarizability, while for the MWCNT stationary phase primarily to LUMO energy followed by polarizability, evidence for a specific interaction between MWCNTs and analytes. The CNT-based hybrid material proved to be not only a chromatographic phase but also a useful tool to investigate the MWCNT-molecular interactions with variously substituted benzenes. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Merli, D; Speltini, A; Dondi, D; Longhi, D; Milanese, C; Profumo, A or concate me.. Safety of 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of 1-Chloro-2-methylbenzene. In 2020 GREEN CHEM published article about PHOTOREDOX CATALYSIS; CARBOXYLIC-ACIDS; TRIFLUOROMETHYLATION; ACTIVATION; ALCOHOLS; ALKYLATION; ALDEHYDES; CLEAVAGE; ESTERS in [Zhu, Xianjin; Liu, Yong; Liu, Can; Yang, Haijun; Fu, Hua] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China in 2020, Cited 59. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8.

Visible light-induced organic reactions are important chemical transformations in organic chemistry, and their efficiency highly depends on suitable photocatalysts. However, the commonly used photocatalysts are precious transition-metal complexes and elaborate organic dyes, which hamper large-scale production due to high cost. Here, for the first time, we report a novel strategy: light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds, allowing high-value-added aromatic ketones and carboxylic acids to be easily prepared in high-to-excellent yields using readily available alkyl arenes, methyl arenes and aldehydes as materials. The mechanistic investigations showed that the treatment of inexpensive and readily available sodium trifluoromethanesulfinate with oxygen under irradiation of light couldin situform a pentacoordinate sulfide intermediate as an efficient photosensitizer. The method represents a highly efficient, economical and environmentally friendly strategy, and the light and oxygen-enabled sodium trifluoromethanesulfinate photocatalytic system represents a breakthrough in photochemistry.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Zhu, XJ; Liu, Y; Liu, C; Yang, HJ; Fu, H or concate me.. Application In Synthesis of 1-Chloro-2-methylbenzene

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, P; Wang, J; Gan, ZX; Zhang, JY; Zeng, RS; Zhao, YS in [Shi, Peng; Wang, Jie; Gan, Zixu; Zhao, Yingsheng] Soochow Univ, Coll Chem Chem Engn & Mat Sci, 199 Renai Rd, Suzhou, Jiangsu, Peoples R China; [Zhang, Jingyu; Zeng, Runsheng] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou, Jiangsu, Peoples R China published A practical copper-catalyzed approach to beta-lactams via radical carboamination of alkenyl carbonyl compounds in 2019.0, Cited 54.0. Product Details of 95-49-8. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8.

Functionalized beta-lactams are highly important motifs in synthetic chemistry. We report an efficient and novel approach to the synthesis of beta-lactams via a copper(i)-catalyzed cascade process involving C(benzyl)-H radical abstraction, intermolecular alkene addition, and intramolecular amination reaction. Variously substituted alkenes were synthesized from vinylacetic acid, leading to the corresponding beta-lactams in moderate to good yields. Preliminary studies indicate that the reaction undergoes a free radical mechanism via a Cu(i)/Cu(ii)/Cu(iii) catalytic cycle.

Product Details of 95-49-8. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Shi, P; Wang, J; Gan, ZX; Zhang, JY; Zeng, RS; Zhao, YS or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An article Dual Ligand-Enabled Nondirected C-H Cyanation of Arenes WOS:000460600600036 published article about PALLADIUM-CATALYZED CYANATION; ELECTRON-DEFICIENT ARENES; AMINO-ACID LIGANDS; BOND CYANATION; ARYL HALIDES; ACTIVATION; FUNCTIONALIZATION; N,N-DIMETHYLFORMAMIDE; OLEFINATION; HETEROARENES in [Chen, Hao; Mondal, Arup; Wedi, Philipp; van Gemmeren, Manuel] Max Planck Inst Chem Energy Convers, Stiftstr 34-36, D-45470 Mulheim, Germany; [van Gemmeren, Manuel] Westfalische Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany in 2019.0, Cited 73.0. COA of Formula: C7H7Cl. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

Aromatic nitriles are key structural units in organic chemistry and, therefore, highly attractive targets for C-H activation. Herein, the development of an arene-limited, nondirected C-H cyanation based on the use of two cooperatively acting commercially available ligands is reported. The reaction enables the cyanation of arenes by C-H activation in the absence of directing groups and is therefore complementary to established approaches.

About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Chen, H; Mondal, A; Wedi, P; van Gemmeren, M or concate me.. COA of Formula: C7H7Cl

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 95-49-8. Authors Hoisington, J; Herrington, JS in MDPI published article about in [Hoisington, Jason; Herrington, Jason S.] Restek Corp, 110 Benner Circle, Bellefonte, PA 16823 USA in 2021.0, Cited 27.0. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

A canister-based sampling method along with preconcentrator-Gas chromatography-Mass Spectrometry (GC-MS) analysis was applied to ethylene oxide (EtO or EO) and 75 other volatile organic compounds (VOCs) in ambient air. Ambient air can contain a large variety of VOCs, and thorough analysis requires non-discriminatory sampling and a chromatographic method capable of resolving a complex mixture. Canister collection of whole air samples allows for the collection of a wide range of volatile compounds, while the simultaneous analysis of ethylene oxide and other VOCs allows for faster throughput than separate methods. The method presented is based on US EPA Method TO-15A and allows for the detection of EtO from 18 to 2500 ppt(v). The method has an average accuracy of 104% and precision of 13% relative standard deviation (RSD), with an instrument run time of 32 min. In addition, a link between canister cleanliness and ethylene oxide growth is observed, and potential mechanisms and cleaning strategies are addressed.

Product Details of 95-49-8. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Hoisington, J; Herrington, JS or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Safety of 2,4-Dichlorobenzoic acid. In 2019 SYNTHESIS-STUTTGART published article about RADIOIODINATION; ARYL; TRACERS in [Dubost, Emmanuelle; Babin, Victor; Benoist, Florian; Hebert, Alexandra; Fabis, Frederic; Cailly, Thomas] Normandie Univ, UNICAEN, CERMN, F-14000 Caen, France; [Pigree, Gilbert; Cailly, Thomas] Normandie Univ, UNICAEN, IMOGERE, F-14000 Caen, France; [Bouillon, Jean-Philippe] Normandie Univ, UNIROUEN, CNRS, INSA Rouen,COBRA UMR 6014, F-76000 Rouen, France; [Cailly, Thomas] CHU Cote Nacre, Dept Nucl Med, F-14000 Caen, France in 2019, Cited 17. The Name is 2,4-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-84-0.

An improved protocol to perform C-H radio-iodination is described. These new conditions allow rapid and clean formation of radio-iodinated N -acylsulfonamides using [ (125) I]NIS and catalytic amounts of palladium acetate and para -toluenesulfonic acid. No pre-functionalized precursors are required and the products are obtained with radiochemical conversions (RCC) of 27-84%.

Safety of 2,4-Dichlorobenzoic acid. About 2,4-Dichlorobenzoic acid, If you have any questions, you can contact Dubost, E; Babin, V; Benoist, F; Hebert, A; Pigree, G; Bouillon, JP; Fabis, F; Cailly, T or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Authors Ray, R; Hartwig, JF in WILEY-V C H VERLAG GMBH published article about in [Ray, Ritwika; Hartwig, John F.] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA in 2021.0, Cited 67.0. Category: chlorides-buliding-blocks. The Name is 1-Chloro-2-methylbenzene. Through research, I have a further understanding and discovery of 95-49-8

Here, we report a class of ligands based on oxalohydrazide cores and N-amino pyrrole and N-amino indole units that generates long-lived copper catalysts for couplings that form the C-O bonds in biaryl ethers. These Cu-catalyzed coupling of phenols with aryl bromides occurred with turnovers up to 8000, a value which is nearly two orders of magnitude higher than those of prior couplings to form biaryl ethers and nearly an order of magnitude higher than those of any prior copper-catalyzed coupling of aryl bromides and chlorides. This ligand also led to copper systems that catalyze the coupling of aryl chlorides with phenols and the coupling of aryl bromides and iodides with primary benzylic and aliphatic alcohols. A wide variety of functional groups including nitriles, halides, ethers, ketones, amines, esters, amides, vinylarenes, alcohols and boronic acid esters were tolerated, and reactions occurred with aryl bromides in pharmaceutically related structures.

Category: chlorides-buliding-blocks. About 1-Chloro-2-methylbenzene, If you have any questions, you can contact Ray, R; Hartwig, JF or concate me.

Reference:
Patent; Nanjing Zhongteng Chemical Co., Ltd.; Zhong Hua; Lu Minshan; Chen Xiuzhen; Liu Qiaobao; Yin Hengbo; Wang Aili; (8 pag.)CN104876790; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality Control of 2,6-Dichlorobenzoic acid. Authors Pacheco-Benichou, A; Ivendengani, E; Kostakis, IK; Besson, T; Fruit, C in MDPI published article about in [Pacheco-Benichou, Alexandra; Ivendengani, Eugenie; Besson, Thierry; Fruit, Corinne] Normandie Univ, UNIROUEN, INSA Rouen, CNRS,COBRA UMR 6014, F-76000 Rouen, France; [Kostakis, Ioannis K.] Natl & Kapodistrian Univ Athens, Dept Pharm, Div Pharmaceut Chem, Athens 15771, Greece in 2021.0, Cited 54.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6

Copper-catalyzed Csp2-Csp2 bond forming reactions through C-H activation are still one of the most useful strategies for the diversification of heterocyclic moieties using various coupling partners. A catalytic protocol for the C-H (hetero)arylation of thiazolo[5,4-f]quinazolin-9(8H)-ones and more generally fused-pyrimidinones using catalyst loading of CuI with diaryliodonium triflates as aryl source under microwave irradiation has been disclosed. The selectivity of the transfer of the aryl group was also disclosed in the case of unsymmetrical diaryliodonium salts. Specific phenylation of valuable fused-pyrimidinones including quinazolinone are provided. This strategy enables a rapid access to an array of various (hetero)arylated N-containing polyheteroaromatics as new potential bioactive compounds.

Quality Control of 2,6-Dichlorobenzoic acid. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Pacheco-Benichou, A; Ivendengani, E; Kostakis, IK; Besson, T; Fruit, C or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Safety of 2,6-Dichlorobenzoic acid. Authors Pacheco-Benichou, A; Ivendengani, E; Kostakis, IK; Besson, T; Fruit, C in MDPI published article about in [Pacheco-Benichou, Alexandra; Ivendengani, Eugenie; Besson, Thierry; Fruit, Corinne] Normandie Univ, UNIROUEN, INSA Rouen, CNRS,COBRA UMR 6014, F-76000 Rouen, France; [Kostakis, Ioannis K.] Natl & Kapodistrian Univ Athens, Dept Pharm, Div Pharmaceut Chem, Athens 15771, Greece in 2021.0, Cited 54.0. The Name is 2,6-Dichlorobenzoic acid. Through research, I have a further understanding and discovery of 50-30-6

Copper-catalyzed Csp2-Csp2 bond forming reactions through C-H activation are still one of the most useful strategies for the diversification of heterocyclic moieties using various coupling partners. A catalytic protocol for the C-H (hetero)arylation of thiazolo[5,4-f]quinazolin-9(8H)-ones and more generally fused-pyrimidinones using catalyst loading of CuI with diaryliodonium triflates as aryl source under microwave irradiation has been disclosed. The selectivity of the transfer of the aryl group was also disclosed in the case of unsymmetrical diaryliodonium salts. Specific phenylation of valuable fused-pyrimidinones including quinazolinone are provided. This strategy enables a rapid access to an array of various (hetero)arylated N-containing polyheteroaromatics as new potential bioactive compounds.

Safety of 2,6-Dichlorobenzoic acid. About 2,6-Dichlorobenzoic acid, If you have any questions, you can contact Pacheco-Benichou, A; Ivendengani, E; Kostakis, IK; Besson, T; Fruit, C or concate me.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics