Reference of 2106-02-7, These common heterocyclic compound, 2106-02-7, name is 2-Chloro-4-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Fully dried 50 mL three-neck eggplant flask(Condenser, with three-way cock, with magnetic stir bar)2-Ethoxyphenbornoronic acid0.50 g (3.0 mmol) (manufactured by Tokyo Chemical Industry Co., Ltd.)2-Chloro-4-fluoroline(Made by Wako Pure Chemical Industries, Ltd.) 0.34 mL (2.9 mmol), 1,3-bis- (2,6-diisopropylphenyl) imidazolium- (allyl) -palladium (II) -chloride(Sigma Aldrich Japan Co., Ltd.)0.008 g (0.028 mmol), barium hydroxide octahydrate (manufactured by Wako Pure Chemical Industries, Ltd.) 0.99 g (3.1 mmol) was added,Isopropyl alcohol (Kanto Chemical Co., Ltd.)It was dissolved in 20 mL and reacted at 80 C. for 6 hours.After the reaction, the solid residue is removed by filtration,The solvent was distilled off under reduced pressure to obtain a crude product.Crude product is silica gel column chromatograph(Eluent: hexane / ethyl acetate = 9/1)Compound 27 was purified by purification using0.66 g (100%, light brown liquid) was obtained.
Statistics shows that 2-Chloro-4-fluoroaniline is playing an increasingly important role. we look forward to future research findings about 2106-02-7.
Reference:
Patent; Mitsui Chemical Inc; Hanada, Shiori; Kinoshita, Shinsuke; Kawamura, Noromori; Muroto, Toshihiro; Tanaka, Kenichi; Ishii, Seiichi; Terao, Hiroshi; Saito, Yasunori; Hara, Retsu; Mizobuchi, Yusuke; (67 pag.)JP5769444; (2015); B2;,
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