Related Products of 1435-48-9,Some common heterocyclic compound, 1435-48-9, name is 2,4-Dichloro-1-fluorobenzene, molecular formula is C6H3Cl2F, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
448 mg of milled sodium hydroxide (1.4 eq; 0.0112 mmol), 1.32 g of 1,3-dichloro-4-fluorobenzene (1 eq; 0.008 mol) and 1.57 g of benzophenone hydrazone (1 eq; 0.008 mol) in 6 ml of degassed tert-amyl alcohol are loaded into a 20 ml reactor surmounted by a condenser, a mechanical stirrer and a temperature sensor, and placed in an inert atmosphere.8.95 mg of palladium acetate (0.001 mol %; 0.00004 mol) and 46.3 mg of 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (0.0008 mol) in 2 ml of degassed tert-amyl alcohol are loaded into a 100 ml Schlenk tube equipped with a magnetic stirrer and placed under an inert atmosphere.After stirring for twenty minutes, the catalyst thus prepared is transferred into the reactor.After stirring at 103 C. for 12 hours, the conversion of the 1,3-dichloro-4-fluorobenzene is complete and a benzophenone N-5-chloro-2-fluorophenylhydrazone yield of 85% (accompanied by 15% of benzophenone N-3-chloro-4-fluorophenylhydrazone) is measured by gas chromatography in the presence of an internal standard (hexacosane).
The synthetic route of 1435-48-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Rhodia Chimie; US7557248; (2009); B2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics