Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2106-02-7, name is 2-Chloro-4-fluoroaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H5ClFN
fd”) 4-Chloro-A^-(2-chloro-4-fluorophenvDpyra2ole-3-carboxamide A mixture of 3,8-dichlorodipyrazolo[l55-a;r95′-d]pyrazine-4,9-dione (0.20 mmol, 51 mg) and 2-chloro-4-fluoroaniline (1.0 mmol, 146 mg) was heated at 12O0C for I h, cooled to ambient temperature and diluted with pentane (5 mL). The precipitate was filtered off and washed with pentane (30 mL). Crystallisation from EtOH:water (4:1, 20 mL) gave 84 mg (77 %) of the title compound as a white solid. 1H NMR (DMSO-d6, 400 MHz) delta 13.8 (br s, IH), 9.65 (s, IH), 8.20 (s, IH), 7.96 (dd, IH), 7.57 (dd, IH), 7.28 (ddd, IH).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BIOLIPOX AB; WO2007/45868; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics