Adding a certain compound to certain chemical reactions, such as: 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6579-54-0, SDS of cas: 6579-54-0
General procedure: To a suspension of 2.5 mmol (2.5 equiv) of NaH (60% in oil) in 5 mL of anhydrous THF was added asolution of 188 mg (1 mmol) of 4-nitro-1-naphthylamine in 1 mL of THF. The mixture was stirred for 10 min at 0C,and 1 mmol of the appropriate benzenesulfonyl chloride was added. The mixture was stirred for 12 h at 25C, quenched with saturated NaHCO3 and extracted with EtOAc. The combined organic layers were washed with brine, dried over anhydrous MgSO4 and concentrated. The crude products were purified by recrystallization and/or chromatography as noted below.
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Reference:
Article; Kril, Liliia M.; Vilchez, Valery; Jiang, Jieyun; Turcios, Lilia; Chen, Changguo; Sviripa, Vitaliy M.; Zhang, Wen; Liu, Chunming; Spear, Brett; Watt, David S.; Gedaly, Roberto; Bioorganic and Medicinal Chemistry Letters; vol. 25; 18; (2015); p. 3897 – 3899;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics