Electric Literature of 29671-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29671-92-9 name is Carbamimidic chloride hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 3; 2-Amino-6- (4-methoxyphenoxymethyl)benzonitrile mg; 0.2 mmol) and chloroformamidine hydrochloride (34.0 mg, 0.30 mmol) were heated at 140 C in diglyme for 3 hours. The reaction mixture was diluted with water, stirred for 2 hours, filtered, washed with water and dried. Purification by silica gel chromatography (5% methanol in dichloromethane) yielded 30 mg of 5-(4- methoxyphenoxymethyl) quinazoline-2,4-diamine.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Carbamimidic chloride hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics