Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 174913-12-3, name is 1-Bromo-3-chloro-5-methoxybenzene, A new synthetic method of this compound is introduced below., COA of Formula: C7H6BrClO
Palladium tetrakis (triphenylphosphine) (174 mg, 0.15 [MMOL)] was added in one portion to a stirred solution of the bromide of Preparation 6 (500 mg, 2.26 [MMOL)] and zinc cyanide (146 mg, 1.24 mmol) in [N, N-DIMETHYLFORMAMIDE] (3 [ML)] at room temperature under a nitrogen atmosphere. The reaction was heated at [100C] for 14 hours and then cooled to room temperature. The solvent was evaporated under reduced pressure and the residue was purified by chromatography on silica gel using ethyl acetate in cyclohexane as eluant (5: 95) to provide the title compound as a yellow oil (380mg). [1H-NMR] [(300MHZ,] [CDC13)] : [8 3.] 82 (s, 3H), 7.04 (s, 1 H), 7.12 (s, 1 H), 7.23 (s, [1 H).] Microanalysis : Found: C, 57.50 ; H, 3.63 ; N, 8.16. [C8H6CINO] requires; C, 57.33 ; H, 3.61 ; N, 8.36%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/29051; (2004); A1;,
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