Application of 1940-29-0,Some common heterocyclic compound, 1940-29-0, name is 4-Bromo-3,5-dichloroaniline, molecular formula is C6H4BrCl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4-bromo-3,5-dichloroaniline (1.00 g, 4.18 mmol) in Ac20 (5 mL) was added pyridine (0.1 mL). The reaction was stirred at room temperature for 2 h. The mixture was poured into 50 mL ice water and extracted with EA (20 mL X 3). The organic layer was washed with brine (50 mL), dried with Na2S04, and concentrated in vacuo to afford product (1 g, 85%). ESI-MS m/z calcd for [CsHeBrCkNOf [M+H]+: 2820; found: 282.0.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-3,5-dichloroaniline, its application will become more common.
Reference:
Patent; GALECTO BIOTECH AB; ZETTERBERG, Fredrik; LEFFLER, Hakon; NILSSON, Ulf; (131 pag.)WO2018/11093; (2018); A1;,
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