Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H5ClF3N
To a stirred solution of 25 (0.05 g, 0.05 mmol) in acetone(0.5 ml) was added K2CO3 (8 mg, 0.06 mmol) and N-phenyl trifluoroacetimidoylchloride (0.01 ml, 0.07 mmol) were added. The reactionmixture was stirred for 3 days under a dry atmosphere at rt.The reaction mixture was dried over MgSO4 and concentrated invacuo. Column chromatography yielded compound 26 (0.056 g,0.05 mmol) in >98% yield. TLC: Rf 0.76 (20% EtOAc/pentane); IR(neat, cm1): 3311, 2954, 2924, 2854, 2112, 1714, 1207, 1151,1112, 731, 696; 1H NMR (400 MHz, CDCl3): d = 7.65-6.78 (m,35H), 5.17-5.16 (m, 1H), 5.06-5.03 (m, 1H), 4.94-4.89 (m, 1H),4.80-4.75 (m, 3H), 4.59-4.55 (m, 3H), 4.46-4.37 (m, 1H), 4.15-3.91 (m, 6H), 3.78-3.58 (m, 5H), 1.07 (s, 9H); 13C NMR (101 MHz,CDCl3): d = 138.3, 138.2, 137.6, 137.5, 135.6, 133.3, 133.1, 129.9,128.8, 128.7, 128.6, 128.5, 128.4, 128.3, 128.2, 128.1, 128.0,127.9, 127.8, 127.6, 124.5, 119.4, 94.5, 77.53, 75.6, 75.1, 74.974.5, 73.6, 73.6, 72.7, 72.0, 70.4, 67.8, 62.7, 61.7, 59.7, 27.0; HRMS:[C64H66F3N7O9Si+Na] requires 1184.45356, found 1184.45410
According to the analysis of related databases, 61881-19-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; van der Es, Daan; Groenia, Nadia A.; Laverde, Diana; Overkleeft, Herman S.; Huebner, Johannes; van der Marel, Gijsbert A.; Codee, Jeroen D.C.; Bioorganic and Medicinal Chemistry; vol. 24; 17; (2016); p. 3893 – 3907;,
Chloride – Wikipedia,
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