Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60811-21-4, name is 4-Bromo-2-chloro-1-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Bromo-2-chloro-1-fluorobenzene
To a solution of 4-bromo-2-chloro-1-fluorobenzene (20 g, 95 mmol) in THF (150mL) was added lithium diisopropylamide (55 mL, 2.0 M in THF, 110 mmol) dropwise at -78C. The resulting mixture was stirred at -78 C for 2 h. Then DMF (11 mL, 142 mmol) was added and the reaction mixture was stirred at -78 C for additonal 2 h. The reaction wasquenched with sat. NH4C1, and extracted with EtOAc. The combined organics were washed with brine, dried over Na2504, and concentrated. The crude residue was purified by flashchromatography to give the title compound. ?H NMR (400 MHz, DM50-cl6) 3 10.71 (s, 1H),8.36(dd,J=8.6Hz,4.7Hz, 1H), 8.18 (t,J 8.8 Hz, 1H).
According to the analysis of related databases, 60811-21-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHANG, Hongjun; BARR, Kenneth, Jay; LAPOINTE, Blair, T.; GUNAYDIN, Hakan; LIU, Kun; TROTTER, B., Wesley; (67 pag.)WO2017/75185; (2017); A1;,
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