Application of 627-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-42-9 name is 2-Methoxyethyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: In a typical run, the appropriate volumes of the reagents (see Table 1 ) were charged into PTFE-coated stainless-steel reactor and heated at 110C for 6h under constant stirring and pressure (N2, 10bar). After cooling to room temperature and removal of acetonitrile, the IL (as chloride; (IL-Cl- IL-Cl- )) was purified by vigorously stirring with cold ethyl acetate (three times, 75mL each time); separated (lower layer) and dried at 40C under reduced pressure over P4O10 for 72h. The IL-OAc- IL-OAc- was obtained by anion exchange (IL-Cl- IL-Cl- ? IL-OH- IL-OH- ; methanol solvent), followed by neutralization of the IL-OH- IL-OH- with acetic acid. The completeness of the (Cl-/OH-) ion-exchange was assured by testing a dilute aqueous solution of the IL-OH- IL-OH- with AgNO3/HNO3 solution. After neutralization, methanol was evaporated under reduced pressure and the IL was dried at 40C under reduced pressure over P4O10 for 96h. The final yield for each IL is shown in Table 1. The structure of the IL was confirmed by 1H NMR spectroscopy
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxyethyl chloride, and friends who are interested can also refer to it.
Reference:
Article; Ferreira, Daniela C.; Oliveira, Mayara L.; Bioni, Thais A.; Nawaz, Haq; King, Alistair W.T.; Kilpelaeinen, Ilkka; Hummel, Michael; Sixta, Herbert; El Seoud, Omar A.; Carbohydrate Polymers; vol. 212; (2019); p. 206 – 214;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics