Synthetic Route of 1996-29-8, The chemical industry reduces the impact on the environment during synthesis 1996-29-8, name is 1-Bromo-4-chloro-2-fluorobenzene, I believe this compound will play a more active role in future production and life.
In a 500 ml round bottom flask1-Bromo-4-chloro-2-fluorobenzene(1-bromo-4-chloro-2-fluorobenzene, 20 g, 95.5 mmol)And methyl anthranilate (15.9 g, 105 mmol), Cesium carbonate (40.4 g, 124 mmol), bis (tri-tert-butylphosphine)Palladium (0.5 g, 1 mmol), and toluene And refluxed with stirring for 7 hours.Cooled to room temperature20 g of Celite 545 was added and stirred for 30 minutes.The reaction solution was filtered and concentrated under reduced pressure. ColumnTo obtain Compound 1 (20.6 g, 73.7 mmol) in a yield of 77.1%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-chloro-2-fluorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LG Chemical Co., Ltd.; Hong, Sung Gil; Kim, Yeon Hwan; Kim, Sung So; Ho, Jung Oh; Cho, Sung Mi; Kim, Hyung Suk; (37 pag.)KR101680413; (2016); B1;,
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