In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15205-11-5, name is 2-Chloro-4-fluorobenzylamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 15205-11-5
General procedure: To a solution of acid 3 (0.384g, 1mmol), HATU (0.38g, 1mmol), and Et3N (1mL) in 20mL of dry CH2Cl2 was added an equimolar amount of the appropriate amine. The mixture was kept stirring at room temperature for 24h. After TLC detection to show no starting materials, the mixture was extracted with 100mL ethyl acetate and washed with saturated NaHCO3 (3×30mL) and saturated NaCl (1×50mL). The organic layers were dried over MgSO4 and evaporated under vacuum. The crude product was purified by column chromatography with methanol: CH2Cl2=1: 30 to obtain intermediates 4a-4u.
The synthetic route of 15205-11-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ju, Han; Zhang, Jian; Sun, Zhuosen; Huang, Zheng; Qi, Wenbao; Huang, Bing; Zhan, Peng; Liu, Xinyong; European Journal of Medicinal Chemistry; vol. 146; (2018); p. 220 – 231;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics