Synthetic Route of 19752-55-7, A common heterocyclic compound, 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, molecular formula is C6H3BrCl2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In Nitrogen environment I-16(99 g, 208 mmol) was dissolved in in 600 mL tetrahydrofuran (THF), where the 1-bromo-3,5-dichlorobenzene(56.4 g, 250 mmol) and tetrakis( triphenylphosphine) palladium was stirred into the (2.40 g, 2.08 mmol) into a saturated potassium carbonate in water (71.9 g, 520 mmol) was heated to reflux at 80 ° C for 8 hours. After the reaction was completed, the reaction solution into water and extracted with dichloromethane (DCM) and then water was removed with anhydrous MgSO4, filter and was concentrated under reduced pressure. Thus the resulting residue was separated and purified by flash column chromatography to obtain the compound I-17(53.7 g, 79percent).
The synthetic route of 19752-55-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Cheil Industries Co., Ltd; Lee, Han Ir; Yu, Uhn Sun; Kang, Dong Min; Kang, Uii Soo; Yang, Yong Tak; Oh, Jae Jin; Yu, Dong Gyu; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; Hong, Jin Suk; (59 pag.)KR2015/6758; (2015); A;,
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