Reference of 108-37-2,Some common heterocyclic compound, 108-37-2, name is 1-Bromo-3-chlorobenzene, molecular formula is C6H4BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A 50 mL roundbottom flask wascharged with 0.5 mmol of aryl halide, benzene (4 mL) and1.5 mmol of KO(t-Bu). The flask was fitted with a refluxcondenser left open to air. Then, a solution of catalyst dissolved in 420 muL DMF was added to the reaction. The reactionwas then stirred and refluxed for 40 h. The reaction was workedup by extraction with ether and washed with deionized H2O.The organic phase was collected and dried over anhydrous sodium sulfate. The residue was purified by flash column chromatography. NMR spectra of isolated products matched well withthe literature.
The synthetic route of 108-37-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tamang, Sem Raj; Hoefelmeyer, James D.; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2757 – 2762;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics