Electric Literature of 38762-41-3, The chemical industry reduces the impact on the environment during synthesis 38762-41-3, name is 4-Bromo-2-chloroaniline, I believe this compound will play a more active role in future production and life.
4-bromo-2-chloroaniline (5 g, 24.2 mmol), cyclopropylboronic acid (4 g, 48.4 mmol), tricyclohexylphosphine (680 mg, 2.42 mmol), palladium acetate (271 mg, 1.21 mmol)and potassium carbonate (15.4 g, 72.6 mmol)were added to 130 mL of a mixture of toluene and water (V:V=25:1). The mixture was heated to 100C and stirred for 12 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography with elution system B to obtain the title compound 24a (2.5 g, yield 61.7%)as a yellow liquid. MS m/z (ESI): 168.1 [M+1]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-chloroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jiangsu Hengrui Medicine Co. Ltd.; Shanghai Hengrui Pharmaceutical Co. Ltd.; YANG, Fanglong; ZHANG, Ling; WANG, Chunfei; HE, Mingxun; HU, Qiyue; HE, Feng; TAO, Weikang; SUN, Piaoyang; (101 pag.)EP3395809; (2018); A1;,
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