Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7149-75-9, name is 4-Chloro-3-methylaniline, A new synthetic method of this compound is introduced below., SDS of cas: 7149-75-9
General procedure: Oxo ester 11-15 (10 mmol) was dissolved in THF(50 ml). Solution of LiOH·H2O (15 mmol) in 20 ml of water was addeddropwise at 5-10 C. After stirring at room temperature (3-8 h, TLCcontrol) the mixture was concentrated to approximately quarter of volume,diluted with 50 ml of water and washed with Et2O (3×30 ml). The waterlayer was acidified with 5% H2SO4 to pH 5, the product was extracted withEt2O (3×30 ml), dried over Na2SO4 and concentrated in vacuo. The crudeoxo acids were unstable and were immediately processed further. Primaryamine (0.55 mmol) and oxo acid (0.50 mmol) were dissolved in EtOH(3.0 ml). Isocyanide (0.55 mmol) was added and the reaction mixture wasstirred at 60-65 C for 12 h, then evaporated in vacuo. The residue was dissolvedin EtOAc (3 ml) and treated with 5 ml of saturated aqueous NaHCO3,the organic layer was separated, the aqueous one was extracted with EtOAc(2×2 ml). The combined organic extracts were washed with water (2×5 ml),dried over Na2SO4 and concentrated in vacuo. The residue was treated with10% EtOAc in Et2O (to cause crystallization of the product), or purifiedby chromatography (silica gel, EtOAc-hexane, 1 : 20 1 : 10). For characteristicsof the products, see Online Supplementary Materials.
The synthetic route of 7149-75-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Stolyarenko, Vasiliy Yu.; Evdokimov, Anatoliy A.; Shishkin, Vladimir I.; Mendeleev Communications; vol. 23; 4; (2013); p. 233 – 234;,
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