Application of 6775-78-6, These common heterocyclic compound, 6775-78-6, name is 6-Chloroimidazo[1,2-b]pyridazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3. 3-Bromo-6-chloro-imidazon , 2-blpyridazine (5)[0140] The 6-Chloro-imidazo[1 ,2-b]pyridazine (4) (500 mg, 0.0032 mol) was taken in glacial acetic acid (5 ml) and bromine (0.4 ml) was added slowly at room temperature. After 20 minutes, solid precipitated out and was filtered. The solid was washed with ether (3 x 15 ml) and dried under air to give 3-Bromo-6-chloro-imidazo[1 ,2-b]pyridazine (5) (400mg, yield = 60%).
The synthetic route of 6775-78-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUPERGEN, INC.; WO2008/58126; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics