In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13526-66-4, name is 3-Bromo-6-chloroimidazo[1,2-b]pyridazine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
To 3-bromo-6-chloroimidazo[1,2-b]pyridazine (100.0 mg, 0.43 mmol) and tetrahydro-2H-pyran-4-ol (48 mg, 0.47 mmol) in N,N-dimethylformamide (2.0 mL) was added sodium hydride (12 mg, 0.52 mmol). The reaction was stirred at room temperature for an hour. Aqueous work-up with saturated NaHCO3 solution and ethyl acetate was followed by drying of the organic phase over MgSO4. After evaporation, 3-bromo-6-(tetrahydropyran-4-yloxy)-imidazo[1,2-b]pyridazine was obtained as an off-white solid (120 mg, 89%).MS (ESI (+)m/z): 297.59 (M+H+)1H NMR (CDCl3-d1, 300 MHz), delta 7.93 (d, J=9.6 Hz, 1H), 7.59 (s, 1H), 6.79 (d, J=9.6 Hz, 1H), 5.24 (m, 1H), 3.94 (m, 2H), 3.59 (m, 2-H), 2.13 (m, 2H), 1.83 (m, 2H).
The synthetic route of 13526-66-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Biogen Idec Ma Inc.; US2011/21513; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics