Reference of 2533-69-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 7; Synthesis of Compounds According to Formula (4); [00528] 5-bromo-2-(trichloromethyl)-lH-benzimidazole 2; To a solution of 4- bromo-o-phenylenediamine 1 (2.52Og, 13.5 mmol) in acetic acid (35mL) cooled to 0 0C was added methyl trichloroacetimidate (2.64Og, 15 mmol) under N2 atmosphere and resulting reaction mixture was stirred at room temperature for 3h. Diluted with water (200 mL) and resulting precipitate was filtered , washed with water (100 mL), dried in vacuum oven at 40 0C to give 5-bromo-2-(trichloromethyl)-lH-benzimidazole (4.1g, 97%). 1H NMR (300 MHz, DMSOd6) : 57.48 (d, J= 6.0 Hz, 1 H), 7.63 (d, J= 6.0 Hz, 1 H), 7.88 (s, 1 H); LCMS mlz 315 (M + H+), ELSD 100%. Reference: Louvet, P.; Lallement, G.; Pernot-Marino, L; Luu- Duc, C; Blanchet, G. Eur. J.Med.Chem. 1993, 28, 71-75.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trichloroacetimidate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CHEMBRIDGE RESEARCH LABORATORIES, INC.; WO2007/56155; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics