Synthetic Route of 63624-28-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63624-28-2, name is 2,4-Dimethoxybenzene-1-sulfonyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 24:Methyl 3-(5-(4-(2,4-dimethoxyphenylsulfonamido)phenyl)thiazol-2-yl) propanoate The compound of example 5 (100 mg) was dissolved in methylene chloride (2 mL) to which pyridine (0.061 mL) was added and the reaction mixture was stirred for 5 min. To this reaction mixture, 2,4-dimethoxybenzene-1 -sulfonyl chloride (0.135 g) was added and the reaction mixture was stirred for 16 h. Water was added into the reaction mixture and the reaction mixture was neutralized with dilute hydrochloric acid. The organic layer was washed with water and dried over anhydrous Na2S04. The solvent was evaporated to obtain an oil, which was purified by column chromatography (silicagel, EtOAc in chloroform) to obtain a solid, which was crystallized using EtOAc in petroleum ether to afford the title compound. Yield: 153 (86 %); 1H NMR (DMSO-d6, 300MHz): delta 10.07 (s, 1 H), 7.88 (s, 1 H), 7.71 (d, 1 H), 7.44 (d, 2H), 7.12 (d, 2H), 6.63 (d, 1 H), 6.57 (dd, 1 H), 3.86 (s, 3H), 3.78 (s, 3H), 3.59 (s, 3H), 3.22 (t, 2H), 2.79 (t, 2H); MS: m/z 463 (M+1 ).
The synthetic route of 2,4-Dimethoxybenzene-1-sulfonyl chloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PIRAMAL LIFE SCIENCES LIMITED; SHARMA, Rajiv; KADAM, Kishorkumar Shivajirao; JADHAV, Ravindra Dnyandev; KANDRE, Shivaji Sadashiv; GUPTE, Amol; WO2012/29032; (2012); A2;,
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