Electric Literature of 2533-69-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step B4-bromo-6-( 1, 1-dimethylethyl)-2-(trichloromethyl)- 1H-benzimidazole[00244] 3-bromo-5-(1 ,1-dimethylethyl)-1 ,2-benzenediamine (1.2 g, 4.9 mmol) was dissolved in acetic acid (25 mL) and methyl 2,2,2-trichloromethylacetimidatate (0.94 mL, 7.4 mmol) was added drop-wise. The reaction was stirred for 3 hours. The mixture was diluted with ethyl ether and washed with water. The aqueous layer was extracted again with ether. The combined organic layers were washed with water, washed with brine, dried over sodium sulfate, and concentrated to give the title compound (0.91 g, 50%). LCMS: m/z 369, 371 , 373 (M+1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trichloroacetimidate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John G; FANG, Jing; PEAT, Andrew James; TAI, Vincent; TURNER, Elizabeth; WO2011/97491; (2011); A1;,
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