Related Products of 1127-85-1, A common heterocyclic compound, 1127-85-1, name is 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline, molecular formula is C8H8Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of NaOH (79.2 mg, 1.98 mmol) in 90% aqueous methanol solution (1.8 mL)A solution of thiophenol (193 muL, 1.89 mmol) in methanol (2.9 mL) was slowly added dropwise at 0 C., The mixture was stirred at room temperature for 1 hour. To the reaction mixture was added 2,4-dichloro-5,6,7,8-tetrahydroquinazoline (350 mg, 1.72 mmol) in methanol (2.9 mL) was slowly added dropwise at 0 C,The mixture was stirred at room temperature for one day.After completion of the reaction was confirmed by TLC,After diluting with ethyl acetate,And extracted with brine. The organic layer was dried over anhydrous Na2SO4,Filtered and concentrated. The concentrated filtrate was separated and purified by silica gel column chromatography (Hex: EtOAc = 20: 1) to obtain the desired compound (475 mg, 99%) as a white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; Nam, Ghil-Soo; Choo, Hyun-Ah; Choi, Kyung-Il; (40 pag.)KR101730790; (2017); B1;,
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