Application of 623-12-1,Some common heterocyclic compound, 623-12-1, name is 1-Chloro-4-methoxybenzene, molecular formula is C7H7ClO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A Schlenk flask was charged with the required aryl chloride (0.50 mmol), arylboronic acid (0.75 mmol), dinuclear NHC-palladium(II) complex (1.0 mol%), KOtBu (2.0equiv), iPrOH (0.4 mL) and H2O (0.8 mL). The mixture was stirred at 80 C for 4 h under N2. After cooling, the reaction mixture was evaporated, and the product was isolated by preparative TLC on silica gel plates.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Chloro-4-methoxybenzene, its application will become more common.
Reference:
Article; Wang, Tao; Xu, Kai; Wang, Wanli; Zhang, Anan; Liu, Lantao; Transition Metal Chemistry; vol. 43; 4; (2018); p. 347 – 353;,
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