In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26487-67-2, name is 1-(2-Chloroethyl)azepane hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1-(2-Chloroethyl)azepane hydrochloride
Example 2: Synthesis of 2-((2-(azepan-1-yl)ethoxy)methyl)pyrazolo[1 ,5-a]pyridine maleate 0.12 g (3 mmol) of a 60percent NaH suspension in mineral oil were added under nitrogen to a solution of pyrazolo[1 ,5-a]pyridin-2-ylmethanol (100 mg, 0.67 mmol) in 5 mL of dry THF. The mixture was stirred for 5 h at room temperature, and after this time, was added 1 -(2-chloroethyl)azepane hydrochloride (201 mg, 1 .01 mmol) suspended in 8 ml_ of THF with 200muIota of triethylamine (TEA). The mixture was heated at 55 5C for 18 h, allowed to cool to room temperature, quenched with water and extracted with EtOAc, and washed with water. The organic layers were dried over Na2S04 and concentrated under vacuum to afford 0.22 g (65percent) of brown oil. Maleate salt was obtained following the same procedure as for example 1 . 1 H NMR (CDCI3) delta ppm: 8.42 (d, J = 6.8 Hz, 1 H), 7.52 (d, J = 8.8 Hz, 1 H), 7.20 – 7.06 (m, 1 H), 6.78 (t, J = 6.9 Hz, 1 H), 6.49 (s, 1 H), 6.30 (s, 2H), 4.74 (s, 2H), 4.08 – 3.89 (m, 2H), 3.70 – 3.51 (m, 2H), 3.36 – 3.25 (m, 2H), 3.19 – 2.99 (m, 2H), 2.15 – 1 .92 (m, 2H), 1 .92 – 1 .72 (m, 4H), 1 .72 – 1 .54 (m, 2H).
The synthetic route of 26487-67-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE S.A.; DIAZ FERNANDEZ, Jose Luis; CUBERES ALTISENT, Mª Rosa; WO2013/124341; (2013); A1;,
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