Electric Literature of 6775-78-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6775-78-6, name is 6-Chloroimidazo[1,2-b]pyridazine, This compound has unique chemical properties. The synthetic route is as follows.
[0192] Step 2. Imidazo[1,2-blpyridazine-6-carboxylic acid methyl ester. A mixture of 6- chloro-imidazo [1 ,2-b]pyridazine (200 mg, 1.30 mmol, 1.00 equiv), bis(triphenylphosphine)palladium(II) dichloride (200 mg, 0.28 mmol, 0.22 equiv), and triethylamine (0.5 mL) in methanol (4 mL) was stirred under carbon monoxide (10 atm) in a 50-mL pressure reactor overnight at 110 C. The solid material was removed by filtration. The filtrate was concentrated under vacuum and the residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (1/1) to give 100 mg (43%) of the titlecompound as a yellow solid. ?H NMR (300 MHz, CDC13) oe 8.16 (s, 1H), 8.08 (d, J = 9.6 Hz, 1H), 7.94 (s, 1H), 7.77 (d, J = 9.6 Hz, 1H), 4.09 (s, 3H).
The chemical industry reduces the impact on the environment during synthesis 6-Chloroimidazo[1,2-b]pyridazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang; WO2013/130935; (2013); A1;,
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