Application of 452-83-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 452-83-5 name is 2-Chloro-5-fluoroaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[2-CHLORO-4-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBOXYLIC] acid cyclopentylmethyl-amide [(100MG] Example 183a), 2-chloro-5-fluoroaniline (ex-Fluorochem, 237mg), and 1,4-dioxan [(1] ml) were stirred at [100C] under nitrogen for 18h. The cooled reaction mixture was evaporated in vacuo, treated with ethyl acetate (5 ml), washed with aqueous 2M hydrochloric acid (2 x [3ML),] followed by water (2×3 ml), and dried [(NA2SO4).] The solution was evaporated in vacuo and the residue purified by mass directed autopreparative purification to give the title compound (35mg). NMR 8 [(CDCL3)] 1.2-1. 35 (2H, m), 1.53-1. 76 (>4H, [M] + H20), 1.78-1. 90 (2H, m), 2.17 [(1H,] [Q),] 3.41 (2H, dd), 5.9 [(1H,] brt), 7.0-7. 11 (2H, m), 7.65-7. 7 [(1H,] m) 8.56 [(1H,] dd), 8.79 [(1H,] s). LC/MS t = 3.67 min, Molecular ion observed [MH+] 417 consistent with the molecular formula C18H17ClF4N4O
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-5-fluoroaniline, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/18433; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics