Reference of 102-49-8,Some common heterocyclic compound, 102-49-8, name is 3,4-Dichlorobenzylamine, molecular formula is C7H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirred solution of tosylate 1 (100 mg, 0.29 mmol) in Acetone or CHCl3 (3 mL) was slowly added amine 2 (0.58 mmol) and ketone 3 (0.87 mmol). Then p-TsOH (25 mg, 0.145 mmol)was addedto the reaction mixture. The resultant mixture was stirred at 60 C for 24 h until the reaction was completed as indicated by TLC. The reaction mixture was concentrated in vacuo, and then extracted with saturated aqueous NaHCO3 and CH2Cl2. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel to give 4 or 5 as syrups.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Dichlorobenzylamine, its application will become more common.
Reference:
Article; Yuan, Wen; Xia, Jianhui; Zhang, Xiaoke; Liang, Peng; Zhang, Jichao; Jiao, Wei; Shao, Huawu; Tetrahedron; vol. 72; 27-28; (2016); p. 3994 – 4000;,
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