Adding a certain compound to certain chemical reactions, such as: 3386-33-2, name is 1-Chlorooctadecane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3386-33-2, Formula: C18H37Cl
EXAMPLE 25 (4-(6,7-bis(stearyloxy)-4-thiaheptanoylamino)benzoyl)glutamic acid di-t-butyl ester To a solution of (4-(6,7-dihydroxy-4-thiaheptanoylamino)benzoyl)glutamic acid di-t-butyl ester as obtained in Reference Example 6 (50 mg) in chloroform (1 ml), triethylamine (0.258 ml), stearyl chloride (0.25 ml) and dimethylaminopyridine (1 mg) were added, followed by stirring at room temperature for 24 hours. After addition of water, the reaction mixture was extracted with ethyl acetate. The extract was washed with a 5% aqueous solution of citric acid, a saturated aqueous solution of sodium hydrogen carbonate and saturated saline, and dried over anhydrous sodium sulfate, and the solvent was distilled off. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to yield the title compound (75 mg, yield 76%) as a wax-like substance. IRupsilonmaxKBr cm-1:3430, 1750, 1710, 1640 1 H-NMR (CDCl3)delta:0.88 (6H, t, J=6.6 Hz), 1.04-1.30 (56H, m), 1.42 (9H, s), 1.49 (9H, s), 1.52-3.15 (18H, m), 4.15 (1H, dd, J=6.8, 12.2 Hz), 4.47 (1H, dd, J=3.2, 12.2 Hz), 4.59-4.73 (1H, m), 5.07-5.24 (1H, m), 6.99 (1H, d, J=7.6 Hz 7.65 (2H, d, J=8.8 Hz), 7.81 (2H, d, J=8.8 Hz), 8.08 (1H, bs)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chlorooctadecane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US5506267; (1996); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics