56961-77-4, These common heterocyclic compound, 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-bromo-2,3-dichlorobenzene (15.0 g, 66.4 mmol) and aniline (12.7 g, 136.1 mmol) were added to toluene in a three-necked flask. Dissolved in 450ml sodium tert-butoxide (9.6g, 99.6mmol), bis (tri-tert-butylphosphine) palladium (0) (0.7 g, 1.3 mmol) was added thereto, followed by stirring for 6 hours under reflux conditions under argon atmosphere. After the reaction was completed, the reaction mixture was cooled to room temperature, H 2 O was added thereto, and the reaction solution was transferred to a separatory funnel to extract. The extract was dried over MgSO 4, concentrated and the sample was purified by silica gel column chromatography to give 14.7 g of intermediate A-1. (Yield 75%)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 56961-77-4.
Reference:
Patent; LG Chem, Ltd.; Seo Sang-deok; Park Tae-yun; Lee Dong-hun; (32 pag.)KR2019/141620; (2019); A;,
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