Related Products of 6306-61-2,Some common heterocyclic compound, 6306-61-2, name is N-(2-Chloroethyl)propan-2-amine hydrochloride, molecular formula is C5H13Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 10 (500 mg; 1.26 mmol) then tetrabutylammonium bromide (203.3 mg; 0.63 mmol) were added to a solution of KOH (1.25 g; 18.9 mmol) in 2- methyltetrahydrofuran (15 mL) and water (1 mL) at rt. The reaction mixture was heated at 50C for 1 h, then 2-isopropylaminoethylchloride hydrochloride (CAS 6306- 61-2) (279 mg; 1.77 mmol) was added. The reaction mixture was heated at 50C for 20 hours. The reaction mixture was cooled to rt, then poured into water and brine. EtOAc was added and the organic layer was washed with brine, dried over MgS04, filtered and evaporated to dryness. The residue (0.7 g) was purified by chromatography over silica gel (irregular SiOH, 15-40muetaiota 30g; mobile phase: 0.4% NH4OH, 98% DCM, 2% MeOH). The pure fractions were collected and evaporated to dryness to give 130 mg which was crystallized from Et20 to give 88 mg (14%) of compound 42. MP.: 75C (gum, Kofler).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-(2-Chloroethyl)propan-2-amine hydrochloride, its application will become more common.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; BERDINI, Valerio; ANGIBAUD, Patrick Rene; WOODHEAD, Steven John; SAXTY, Gordon; WO2013/61074; (2013); A1;,
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