Related Products of 2533-69-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2533-69-9, name is Methyl 2,2,2-trichloroacetimidate, This compound has unique chemical properties. The synthetic route is as follows.
4-Nitrobenzene-1,2-diamine 1a (19.33g, 126mmol) was suspended in 200mL of glacial acetic acid, methyl 2,2,2-trichloroacetimidate 2a (24.5g, 139mmol) was added dropwise. The mixture was stirred at room temperature until a large amount of solid precipitated. The reaction solution was diluted with 200mL of glacial acetic acid, and then 500g of crushed ice and 100mL of ice water were added, stirred until the ice dissolved. The solution was subjected to suction filtration. The filter cake was washed with water (20mL*5) and subjected to infrared drying to obtain 5-nitro-2-(trichloromethyl)-1H-benzo[d]imidazole 2b (27g, yellow solid), yield: 69%. MS m / z (ESI): 281.8 [M + 1]
The chemical industry reduces the impact on the environment during synthesis Methyl 2,2,2-trichloroacetimidate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Zhejiang Hisun Pharmaceutical Co., Ltd; CHEN, Lei; GUAN, Dongliang; BAI, Hua; YAN, Xing; MIAO, Shuai; ZHU, Songsong; (54 pag.)EP3339305; (2018); A1;,
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