Application of 626-43-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 626-43-7, name is 3,5-Dichloroaniline, This compound has unique chemical properties. The synthetic route is as follows.
5.2.1 5,7-Dichloro-2-methylquinoline (B-TDMQ5) To a solution of 3,5-dichloroaniline (3.24 g, 20 mmol) in HCl (12 M, 15 mL) at 0 C acetaldehyde was added dropwise, under stirring. The reaction medium was kept at 0 C for 15 min and the temperature was gradually increased to 80 C. The mixture was stirred at 80 C for 4 h. The resulting mixture was poured into ice-cold water and neutralized with aqueous ammonium. After extraction with CH2Cl2, the organic phase was dried over Na2SO4, filtered, and concentrated under reduced pressure. The crude mixture was purified by silica gel flash column chromatography (ethyl acetate/petroleum ether, 1/20, v/v). After evaporation of the eluent, B-TDMQ5 was obtained as a yellow solid (2.88 g, 68%). 1H NMR (400 MHz, CDCl3): delta = 8.40 (d, J = 8.0 Hz, 1H), 7.96 (d, J = 2.0 Hz, 1H), 7.55 (d, J =2.0 Hz, 1H), 7.37 (d, J = 8.0 Hz, 1H), 2.76 (s, 3H).
The chemical industry reduces the impact on the environment during synthesis 3,5-Dichloroaniline. I believe this compound will play a more active role in future production and life.
Reference:
Article; Zhang, Weixin; Huang, Meijie; Bijani, Christian; Liu, Yan; Robert, Anne; Meunier, Bernard; Comptes Rendus Chimie; vol. 21; 5; (2018); p. 475 – 483;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics