Some common heterocyclic compound, 699-89-8, name is 4,7-Dichlorothieno[2,3-d]pyridazine, molecular formula is C6H2Cl2N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4,7-Dichlorothieno[2,3-d]pyridazine
A 250 mL, round-bottomed flask was equipped with a stir bar and reflux condenser. To the flask was added the product of step 4 (7.65 g, 37.3 mmol), 4-chloroaniline (4.76, 37.3 mmol) in EtOH (75 mL). The mixture was refluxed for 3 h. An orange solid precipitated from the reaction after 3 h. The reaction was cooled to rt and the solid was collected by filtration and washed with hexane. The desired 7-chloro-4-(4-chlorophenylamino)thieno[2,3-d]pyridazine was obtained (6.5 g, 21.9 mmol; 60% yield); mp=139-142 C.; ES MS (M+H)+=297; TLC (Hexane-EtOAc, 60:40); Rf=0.48.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 699-89-8, its application will become more common.
Reference:
Patent; Bayer Pharmaceuticals Corporation; US6689883; (2004); B1;,
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