Electric Literature of 94-97-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 94-97-3 name is 5-Chloro-1H-benzo[d][1,2,3]triazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 5-chloro-1/-/-benzotriazole (1 53 g) in THF was added at 0C to a mixture of diisopropylic azodicarboxylate (2 ml_), triphenyl phosphine (2.9 g) and allyl alcohol (1.4 mL) in THF. After stirring one hour at 00C, the mixture was concentrated under reduced pressure to give a residue that was purified by chromatography (SiO2, heptane/EA) to afford 2-allyl-5-chloro-2/-/-benzotriazole (1.02 g, 53%). A mixture of 1- allyl-5-chloro-1/-/-benzotriazole and 1-allyl-6-chloro-1/-/-benzotriazole was also recovered (0.9 g, 47%). Alternatively, 2-allyl-5-chloro-2H-benzotriazole [4.87 g, 25%,Rf =0.4 (1 :3 EA/heptane)] was obtained using a procedure similar to that described in Example 1 , part a, except using 3-bromopropene. Similarly, a mixture of 1-allyl-5- chloro-1 H-benzotriazole and 1-allyl-6-chloro-1/-/-benzotriazole was also recovered [10.81 g, 56%, Rf =0.2 (1 :3 EA/heptane)]
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-1H-benzo[d][1,2,3]triazole, and friends who are interested can also refer to it.
Reference:
Patent; MERIAL LIMITED; AVENTIS AGRICULTURE; WO2008/144275; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics